Research article in Structure
In our recent article published in the Structure (Cell Press), entitled: "Monitoring the conformational ensemble...
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Mechanosensation is the ability of ion channels to sense and respond to tension changes within membranes by opening their pores, through which ions flow.
In our lab we investigate the molecular basis of mechanosensation and its role in the regulation of ion channels.
The main methods we employ to structurally investigate mechanosensitive ion channels are Electron Paramagnetic Resonance (EPR) spectroscopy, Pulsed ELectron-electron DOuble Resonance (PELDOR), also known as Double Electron-Electron Resonance (DEER) spectroscopy and Cryo Electron Microscopy (cryoEM). We functionally characterise these systems by employing single molecule electrophysiology methods.
