A new research article by the Pliotas Lab in collaboration with the Diallinas Lab has been published in the journal Channels. In the study entitled “Genetic and cellular characterization of MscS-like putative channels in the filamentous fungus Aspergillus nidulans” we characterize two MscS-like putative channels, named MscA and MscB, from the model filamentous fungus Aspergillus nidulans. Orthologues of MscA and MscB are present in most fungi, including relative plant and animal pathogens. We show that MscA and MscB localize in Endoplasmic Reticulum and the Plasma Membrane respectively, whereas their overexpression leads to increased CaCl2 toxicity and/or reduction of asexual spore formation. Our findings contribute to understanding the role of MscS-like channels in filamentous fungi and relative pathogens.
